Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
Identifieur interne : 000195 ( Main/Exploration ); précédent : 000194; suivant : 000196Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
Auteurs : Soufiane Boucetta [Canada] ; Ali Salimi [Canada] ; Mahsa Dadar [Canada] ; Barbara E. Jones [Canada] ; D. Louis Collins [Canada] ; Thien Thanh Dang-Vu [Canada]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson’s disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples of magnetic resonance imaging (MRI) scans in 69 PD patients with probable RBD, 240 patients without RBD and 138 healthy controls, using deformation-based morphometry (p < 0.05 corrected for multiple comparisons). All data were extracted from the Parkinson’s Progression Markers Initiative. PD patients with probable RBD showed smaller volumes than patients without RBD and than healthy controls in the pontomesencephalic tegmentum, medullary reticular formation, hypothalamus, thalamus, putamen, amygdala and anterior cingulate cortex. These results demonstrate that RBD is associated with a prominent loss of volume in the pontomesencephalic tegmentum, where cholinergic, GABAergic and glutamatergic neurons are located and implicated in the promotion of REM sleep and muscle atonia. It is additionally associated with more widespread atrophy in other subcortical and cortical regions whose loss also likely contributes to the altered regulation of sleep-wake states and motor activity underlying RBD in PD patients.
Url:
DOI: 10.1038/srep26782
PubMed: 27245317
PubMed Central: 4887790
Affiliations:
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Louis Collins</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Montreal Neurological Institute, McGill University</institution>, 3801 University Street, Montréal, Québec, H3A 2B4<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dang Vu, Thien Thanh" sort="Dang Vu, Thien Thanh" uniqKey="Dang Vu T" first="Thien Thanh" last="Dang-Vu">Thien Thanh Dang-Vu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Studies in Behavioural Neurobiology, PERFORM Center and Dpt of Exercise Science, Concordia University</institution>, 7141 Sherbrooke St. West, Montréal, Québec, H4B 1R6<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal and Dpt of Neurosciences, Université de Montréal</institution>, 4545 Chemin Queen Mary, Montréal, Québec, H3W 1W4<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson’s disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples of magnetic resonance imaging (MRI) scans in 69 PD patients with probable RBD, 240 patients without RBD and 138 healthy controls, using deformation-based morphometry (p < 0.05 corrected for multiple comparisons). All data were extracted from the Parkinson’s Progression Markers Initiative. PD patients with probable RBD showed smaller volumes than patients without RBD and than healthy controls in the pontomesencephalic tegmentum, medullary reticular formation, hypothalamus, thalamus, putamen, amygdala and anterior cingulate cortex. These results demonstrate that RBD is associated with a prominent loss of volume in the pontomesencephalic tegmentum, where cholinergic, GABAergic and glutamatergic neurons are located and implicated in the promotion of REM sleep and muscle atonia. It is additionally associated with more widespread atrophy in other subcortical and cortical regions whose loss also likely contributes to the altered regulation of sleep-wake states and motor activity underlying RBD in PD patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schenck, C H" uniqKey="Schenck C">C. H. Schenck</name></author><author><name sortKey="Mahowald, M W" uniqKey="Mahowald M">M. W. Mahowald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeve, B F" uniqKey="Boeve B">B. F. Boeve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peever, J" uniqKey="Peever J">J. Peever</name></author><author><name sortKey="Luppi, P H" uniqKey="Luppi P">P. H. Luppi</name></author><author><name sortKey="Montplaisir, J" uniqKey="Montplaisir J">J. 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Stiasny-Kolster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahlknecht, P" uniqKey="Mahlknecht P">P. Mahlknecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albaugh, M D" uniqKey="Albaugh M">M. D. Albaugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eskildsen, S F" uniqKey="Eskildsen S">S. F. Eskildsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K. Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnack, H G" uniqKey="Schnack H">H. G. Schnack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Soelen, I L" uniqKey="Van Soelen I">I. L. van Soelen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, M K" uniqKey="Chung M">M. K. Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carducci, F" uniqKey="Carducci F">F. Carducci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padovani, A" uniqKey="Padovani A">A. Padovani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unger, M M" uniqKey="Unger M">M. M. Unger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Boucetta, Soufiane" sort="Boucetta, Soufiane" uniqKey="Boucetta S" first="Soufiane" last="Boucetta">Soufiane Boucetta</name></noRegion><name sortKey="Boucetta, Soufiane" sort="Boucetta, Soufiane" uniqKey="Boucetta S" first="Soufiane" last="Boucetta">Soufiane Boucetta</name><name sortKey="Collins, D Louis" sort="Collins, D Louis" uniqKey="Collins D" first="D. Louis" last="Collins">D. Louis Collins</name><name sortKey="Dadar, Mahsa" sort="Dadar, Mahsa" uniqKey="Dadar M" first="Mahsa" last="Dadar">Mahsa Dadar</name><name sortKey="Dang Vu, Thien Thanh" sort="Dang Vu, Thien Thanh" uniqKey="Dang Vu T" first="Thien Thanh" last="Dang-Vu">Thien Thanh Dang-Vu</name><name sortKey="Dang Vu, Thien Thanh" sort="Dang Vu, Thien Thanh" uniqKey="Dang Vu T" first="Thien Thanh" last="Dang-Vu">Thien Thanh Dang-Vu</name><name sortKey="Jones, Barbara E" sort="Jones, Barbara E" uniqKey="Jones B" first="Barbara E." last="Jones">Barbara E. Jones</name><name sortKey="Salimi, Ali" sort="Salimi, Ali" uniqKey="Salimi A" first="Ali" last="Salimi">Ali Salimi</name><name sortKey="Salimi, Ali" sort="Salimi, Ali" uniqKey="Salimi A" first="Ali" last="Salimi">Ali Salimi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
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